Effect of switching of previous nucleos(t)ide analogues to Tenofovir on Hepatitis B surface antigen levels

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  • Okuse Chiaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Hiraishi Tetsuya
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Ishii Toshiya
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Morita Nozomi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Suetani Keigo
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Ishigooka Shinya
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Ikeda Hiroki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Watanabe Tsunamasa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Matsunaga Kotaro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Matsumoto Nobuyuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Takahashi Hideaki
    Division of Gastroenterology, Department of Internal Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
  • Yotsuyanagi Hiroshi
    Division of Infectious Disease, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo
  • Itoh Fumio
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Suzuki Michihiro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital

Bibliographic Information

Other Title
  • 先行する核酸アナログ製剤からテノホビルへの変更がHBs抗原量に及ぼす影響
  • センコウ スル カクサン アナログ セイザイ カラ テノホビル エ ノ ヘンコウ ガ HBs コウゲンリョウ ニ オヨボス エイキョウ

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Abstract

<p>Hepatitis B surface antigen (HBsAg) levels in sixteen patients who underwent switching of previous nucleos(t)ide analogues (NAs) to Tenofovir (TDF) were evaluated. Patients were classified into Adefovir (ADF)-pretreated group and Entecavir (ETV)-pretreated group. HBsAg levels were significantly decreased throughout the course, especially after administration of TDF in all patients. In ADF-pretreated group, no significant difference of HBsAg levels was observed before and after administration of TDF. On the other hand, HBsAg levels after administration of TDF were significant decreased, while no significant difference was observed before administration of TDF in ETV-pretreated group. As conclusion, it is suspected that administration of TDF may have some effect on control of HBsAg levels.</p>

Journal

  • Kanzo

    Kanzo 58 (6), 354-356, 2017

    The Japan Society of Hepatology

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