Comparative Anatomy of Gastrin-releasing Peptide Pathways in the Trigeminal Sensory System of Mouse and the Asian House Musk Shrew <i>Suncus murinus</i>

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Author(s)

    • Takanami Keiko
    • Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University|Anatomy and Neurobiology, Kyoto Prefectural University of Medicine
    • Inoue Kaihei
    • Anatomy and Neurobiology, Kyoto Prefectural University of Medicine
    • Mukai Hiroki
    • Anatomy and Neurobiology, Kyoto Prefectural University of Medicine
    • Tamura Kei
    • Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
    • Jogahara Takamichi
    • Laboratory of Animal Management and Resources, Department of Zoology, Okayama University of Science|Division of Bio-resources, Department of Biotechnology, Frontier Science Research Center, University of Miyazaki
    • Oda Sen-ichi
    • Laboratory of Animal Management and Resources, Department of Zoology, Okayama University of Science
    • Kawata Mitsuhiro
    • Anatomy and Neurobiology, Kyoto Prefectural University of Medicine|School of Health Science, Bukkyo University
    • Sakamoto Tatsuya
    • Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
    • Sakamoto Hirotaka
    • Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University

Abstract

<p>Gastrin-releasing peptide (GRP) has recently been identified as an itch-signaling molecule in the primary afferents and spinal cord of rodents. However, little information exists on the expression and localization of GRP in the trigeminal somatosensory system other than in rats. We examined the generality of the trigeminal GRP system in mammals using two distinct species, suncus as a model of specialized placental mammals known to have a well-developed trigeminal sensory system and mice as a representative small laboratory animal. We first analyzed the gross morphology of the trigeminal somatosensory system in suncus to provide a brainstem atlas on which to map GRP distribution. Immunohistochemical analyses showed that 8% of trigeminal ganglion neurons in suncus and 6% in mice expressed GRP. Expression was restricted to cells with smaller somata. The GRP-containing fibers were densely distributed in the superficial layers of the caudal part of the trigeminal spinal nucleus (Vc) but rare in the rostral parts, both in suncus and mice. Expression of GRP receptor mRNA and protein was also detected in the Vc of suncus. Taken together, these results suggest that the trigeminal GRP system mediating itch sensation is conserved in mammals.</p>

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 49(6), 181-190, 2016

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

Codes

  • NII Article ID (NAID)
    130006856396
  • Text Lang
    ENG
  • ISSN
    0044-5991
  • Data Source
    J-STAGE 
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