Efficacy of Intravenous Cyclophosphamide Pulse Therapy for P-Glycoprotein-expressing B Cell-associated Active True Renal Lupus Vasculitis in Lupus Nephritis
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- Kawabe Akio
- The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
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- Tsujimura Shizuyo
- The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
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- Saito Kazuyoshi
- The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
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- Tanaka Yoshiya
- The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
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抄録
<p>True renal lupus vasculitis (TRLV), a vascular lesion usually associated with proliferative lupus nephritis (LN), is resistant to conventional treatments. The expression of P-glycoprotein (P-gp) on activated lymphocytes causes drug resistance. We herein report a patient with TRLV, minimal change LN, overexpression of P-gp on peripheral B cells, and accumulation of P-gp+ B cells at the site of TRLV. High-dose corticosteroids combined with intravenous cyclophosphamide pulse therapy resulted in clinical remission and the long-term normal renal function. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 56 (12), 1575-1580, 2017
一般社団法人 日本内科学会