Graves' Disease in Pediatric and Elderly Patients with 22q11.2 Deletion Syndrome
-
- Ueda Yoko
- The First Department of Medicine, Wakayama Medical University, Japan
-
- Uraki Shinsuke
- The First Department of Medicine, Wakayama Medical University, Japan
-
- Inaba Hidefumi
- The First Department of Medicine, Wakayama Medical University, Japan
-
- Nakashima Sakiko
- The First Department of Medicine, Wakayama Medical University, Japan
-
- Ariyasu Hiroyuki
- The First Department of Medicine, Wakayama Medical University, Japan
-
- Iwakura Hiroshi
- The First Department of Medicine, Wakayama Medical University, Japan
-
- Ota Takayuki
- The First Department of Medicine, Wakayama Medical University, Japan
-
- Furuta Hiroto
- The First Department of Medicine, Wakayama Medical University, Japan
-
- Nishi Masahiro
- The First Department of Medicine, Wakayama Medical University, Japan
-
- Akamizu Takashi
- The First Department of Medicine, Wakayama Medical University, Japan
Search this article
Abstract
<p>22q11.2 Deletion Syndrome (22qDS) is often complicated by autoimmune diseases. To clarify the causal relationship, we examined the lymphocyte subset distribution and the human leucocyte antigen (HLA) in two female patients (one child and an elderly) with Graves' disease (GD) and 22qDS. Thymus dysgenesis might have contributed to the T-cell imbalance and the lack of negative selection in both cases. Notably, HLA-DR14, a known risk factor for GD in Japanese individuals and the decreased regulatory T-cell numbers that were seen in the pediatric case, may affect the early onset of GD. Central and peripheral tolerance and Th1 cells appeared to be associated with the pathogenesis of GD in 22qDS. </p>
Journal
-
- Internal Medicine
-
Internal Medicine 56 (10), 1169-1173, 2017
The Japanese Society of Internal Medicine