Mizoribine Synchronized Methotrexate Therapy should be Considered when Treating Rheumatoid Arthritis Patients with an Inadequate Response to Various Combination Therapies
-
- Ikeda Keigo
- Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan Institutes for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Japan
-
- Watanabe Kozo
- Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan Institutes for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Japan
-
- Hirai Takuya
- Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan Institutes for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Japan
-
- Tanji Kana
- Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Japan
-
- Miyashita Tomoko
- Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan
-
- Nakajima Shihoko
- Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Japan
-
- Uomori Kaori
- Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Japan
-
- Morimoto Shinji
- Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan Institutes for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Japan
-
- Takamori Kenji
- Institutes for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Japan
-
- Ogawa Hideoki
- Institutes for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Japan
-
- Takasaki Yoshinari
- Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Japan
-
- Sekigawa Iwao
- Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan Institutes for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Japan
Search this article
Abstract
<p>Objective The objective of this study was to confirm the efficacy of low-dose mizoribine (MZR), an inhibitor of inosine monophosphate dehydrogenase, as part of synchronized methotrexate (MTX) therapy for rheumatoid arthritis (RA) patients with an inadequate response to various combination therapies of MTX, other synthetic disease-modifying anti-rheumatic drugs (DMARDs) and biological DMARDs. </p><p>Methods Low-dose MZR was administered to 56 uncontrolled RA patients being treated with MTX and various biological DMARDs. The observation period was 12 months, and the disease activity was evaluated based on the Disease Activity Score in 28 joints (DAS28)-ESR, Simplified Disease Activity Index (SDAI) and serum MMP-3 level. </p><p>Results All of the disease activity indices were significantly improved within three months, and the serum MMP-3 levels were also significantly decreased around four months after starting low-dose MZR therapy. No patients experienced any adverse effects. </p><p>Conclusion The present preliminary findings suggest that low-dose MZR therapy with MTX should be considered for the treatment of RA patients with an inadequate response to various combination therapies including MTX, other synthetic DMARDs and biological DMARDs or in whom increasing the dose of MTX is difficult for reasons such as adverse effects and complications. </p>
Journal
-
- Internal Medicine
-
Internal Medicine 56 (10), 1147-1152, 2017
The Japanese Society of Internal Medicine