A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis
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- Fujigaki Yoshihide
- Department of Internal Medicine, Teikyo University School of Medicine, Japan Central Laboratory, Teikyo University School of Medicine, Japan
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- Tamura Yoshifuru
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Shibata Shigeru
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Kondo Fukuo
- Department of Pathology, Teikyo University School of Medicine, Japan
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- Iwakura Takamasa
- Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan
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- Kojima Kenichiro
- Division of Nephrology, Ageo Central General Hospital, Japan
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- Yamaguchi Yutaka
- Department of Pathology, Teikyo University School of Medicine, Japan
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- Uchida Shunya
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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<p>A 71-year-old man with hypertension and diabetes mellitus presented with proteinuria. Laboratory data showed proteinuria of 3.1 g/g creatinine, serum albumin of 3.5 g/dL and serum creatinine of 1.03 mg/dL without autoantibodies. A renal biopsy revealed segmental granular IgG depositions on glomerular capillary walls. Electron microscopy showed segmentally subepithelial, intramembranous and mesangial deposits. Diffuse segmental membranous glomerulonephritis (MGN) was diagnosed with only IgG1 deposition and without M-type phospholipase A2 receptor or thrombospondin type-1 domain-containing 7A staining, suggesting secondary MGN with an unknown target antigen in immune deposits. Physicians should keep in mind the existence of segmental MGN to better understand the clinicopathological characteristics. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 56 (13), 1691-1695, 2017
一般社団法人 日本内科学会