Synapse-specific effects of IL-1beta on long-term potentiation in the mouse hippocampus.

• HOSHINO Koji

  Department of Anesthesiology and Cristical Care Medicine, Hokkaido University Graduate School of medicine Department of Neurobiology, Hokkaido University Graduate School of Medicine

• HASEGAWA Kan

  Department of Anesthesiology and Cristical Care Medicine, Hokkaido University Graduate School of medicine Department of Neurobiology, Hokkaido University Graduate School of Medicine

• KAMIYA Haruyuki

  Department of Neurobiology, Hokkaido University Graduate School of Medicine

• MORIMOTO Yuji

  Department of Anesthesiology and Cristical Care Medicine, Hokkaido University Graduate School of medicine

書誌事項

タイトル別名

• <b>Synapse-specific effects of IL-1β on long-term potentiation in the mouse hip</b><b>pocampus </b>

抄録

Interleukin-1β (IL-1β) is a key molecule in the inflammatory responses elicited during infection and injury. It exerts local effects on synaptic plasticity by binding to IL-1 receptors that are expressed at high levels in the hippocampus. We examined the effects of IL-1β on synaptic plasticity in different hippocampal regions in acute mouse brain slices by measuring long-term potentiation (LTP). IL-1β (1 ng/mL) was applied for 30 min before LTP was induced with high-frequency stimulation (HFS). LTP was significantly impaired by either IL-1β application to the Schaffer collateral-CA1 synapses or the associational/commissural (A/C) fiber-CA3 synapses, which are both dependent on N-methyl-D-aspartate (NMDA) receptor activation. However, mossy fiber-CA3 LTP, which is expressed presynaptically in an NMDA-independent manner, was not impaired by IL-1β. Our results demonstrate that IL-1β exerts variable effects on LTP at different kinds of synapses, indicating that IL-1β has synapse-specific effects on hippocampal synaptic plasticity.

収録刊行物

• Biomedical Research

  Biomedical Research 38 (3), 183-188, 2017

  バイオメディカルリサーチプレス

キーワード

• General Biochemistry, Genetics and Molecular Biology
• General Medicine

詳細情報

• CRID: 1390001204902239744
• NII論文ID: 130006865611
• DOI: 10.2220/biomedres.38.183
• ISSN: 1880313X
• ISSN: 03886107
• HANDLE: 2115/67301
• PubMed: 28637953
• Web Site: https://www.jstage.jst.go.jp/article/biomedres/38/3/38_183/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018114697
• 本文言語コード: en
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  • IRDB
  • Crossref
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