NUTRITIVE VALUE OR TOXICITY OF HIGHLY UNSATURATED FATTY ACIDS. I
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It has been widely accepted that the nutritive value of unsaturated fatty acids is depleted when the number of double bond in the acids increases. In order to prove whether this is true or not, we have carried out the following experiments, using the diet consisting of highly unsaturated fatty acids.<br> 1. When the diet, containing 5 per cent of ethyl ester of highly unsaturated fatty acids kept from the oxidation as much as possible, was administered to the test rats together with a small amount of yeast (3 per cent), the normal growth of the rats was attained without showing retarding effects on their health. The nutritive value of the test ester was not much lower than that of oleic acid used for the comparison.<br> 2. The rats, which were fed with the acids obtained from the same source and autoxidized, exhibited a retarding effect upon their growth with the decrease in weight and the depilation around their mouths and legs. They all died in the later course of the test.<br> On the basis of these assays, we have come to the conclusion that highly unsaturated fatty acids contained in fresh fish will not be harmful at all for the health of animals.<br> We hereby highly appreciate the helpful advices given by Dr. Jun'ichi O-zaki, and the constant encouragement by Dr. Hideo Higashi. We are also much indebted to the unselfish devotion of Misses Hisae Sakurai and Kimie Araiin the feeding of animals.
- The Journal of Biochemistry
The Journal of Biochemistry 41(3), 327-335, 1954
The Japanese Biochemical Society