ω3脂肪酸の代謝と抗炎症作用に関する研究  [in Japanese] Omega-3 fatty acid metabolism in controlling inflammation and related diseases  [in Japanese]

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Author(s)

    • 有田 誠 Arita Makoto
    • 慶應義塾大学薬学部代謝生理化学講座|理化学研究所統合生命医科学研究センターメタボローム研究チーム|横浜市立大学大学院生命医科学研究科 Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy|Laboratory for Metabolomics,RIKEN Center for Integrative Medical Sciences(IMS)|Graduate School of Medical Life Science, Yokohama City University

Abstract

Dietary supplementation of omega-3 polyunsaturated fatty acid(PUFA)includingeicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA)is widely held to be beneficial in human health. Also, elevation in omega-3 PUFA levels in omega-3desaturase( fat-1)transgenic mice that endogenously biosynthesize omega-3 PUFA from omega-6 PUFA exhibits resistance to inflammatory disease models. To elucidate the molecular mechanisms underlying the beneficial effects of omega-3 PUFAs, we developed a comprehensive LC-MS/MS-based lipidomics method that can detect and quantify more than 500 of PUFA metabolites simultaneously. Using this lipidomics system, and genetically modified animals or nutritional control to manipulate fatty acid balance in the body, we try to understand how different balance of omega-3/omega-6 fatty acids and their unique metabolites function in vivo that could explain the biological significance of omega-3 PUFAs in controlling inflammation and related diseases.

Journal

  • Journal of Lipid Nutrition

    Journal of Lipid Nutrition 26(1), 27-34, 2017

    Japan Society for Lipid Nutrition

Codes

  • NII Article ID (NAID)
    130006894081
  • NII NACSIS-CAT ID (NCID)
    AN10526430
  • Text Lang
    JPN
  • ISSN
    1343-4594
  • NDL Article ID
    028126890
  • NDL Call No.
    Z74-B12
  • Data Source
    NDL  J-STAGE 
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