<b>Expression of IL-34 in Root Resorption by Excessive Orthodontic Force </b>

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Author(s)

    • Kohno Ryoko
    • Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
    • Yamaguchi Masaru
    • Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
    • Hikida Takuji
    • Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
    • Kikuta Jun
    • Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
    • Shimizu Mami
    • Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
    • Takahashi-Hikida Momoko
    • Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
    • Murakami Yoshiki
    • Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
    • Kasai Kazutaka
    • Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

Abstract

<p>Interleukin-34(IL-34)was recently discovered and shown to mediate inflammation and osteoclastogenesis. An <i>in vitro</i> study reported that the expression of IL-34 is stimulated by tumor necrosis factor-α<i> </i>via nuclear factor-kB activation in osteoblasts. The present study focused on the expression of IL-34 in resorbed root cementum using an experimental rat model of tooth movement.</p><p>Experimental tooth movement was induced by a quad helix-type device. The upper first molar was palatally moved by the appliance with a force of 10 or 50g for 21 days. We performed hematoxylin and eosin and immunohistochemistry staining for tartrateresistant acid phosphatase and IL-34 in the root resorption area.</p><p>In the heavy force(50g)group, few IL-34-positive odontoclasts were observed on day 7 in the root, but increased at days 14 and 21. Therefore, IL-34 may take part in the aggravation of root resorption.</p>

Journal

  • International Journal of Oral-Medical Sciences

    International Journal of Oral-Medical Sciences 16(1), 8-15, 2017

    Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo

Codes

  • NII Article ID (NAID)
    130006894958
  • Text Lang
    ENG
  • ISSN
    1347-9733
  • Data Source
    J-STAGE 
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