Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients
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- Suzuki Jun-ichi
- Department of Advanced Clinical Science and Therapeutics, The University of Tokyo
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- Imai Yasushi
- Department of Cardiovascular Medicine, The University of Tokyo
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- Aoki Mieko
- Department of Cardiovascular Medicine, The University of Tokyo
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- Fujita Daishi
- Department of Cardiovascular Medicine, The University of Tokyo
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- Takeda Norifumi
- Department of Cardiovascular Medicine, The University of Tokyo
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- Aoyama Norio
- Department of Periodontology, Tokyo Medical and Dental University
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- Wakayama Kouji
- Department of Advanced Clinical Science and Therapeutics, The University of Tokyo
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- Ikeda Yuichi
- Department of Cardiovascular Medicine, The University of Tokyo
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- Kumagai Hidetoshi
- Department of Advanced Clinical Science and Therapeutics, The University of Tokyo
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- Akazawa Hiroshi
- Department of Cardiovascular Medicine, The University of Tokyo
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- Izumi Yuichi
- Department of Periodontology, Tokyo Medical and Dental University
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- Isobe Mitsuaki
- Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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- Komuro Issei
- Department of Cardiovascular Medicine, The University of Tokyo
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- Hirata Yasunobu
- Department of Tokyo Teishin Hospital
Abstract
<p>Marfan syndrome (MFS) is a systemic connective tissue disorder that is caused by mutations of fibrillin-1. While MFS patients are at a high risk of periodontitis and aortic diseases, little causal information has been provided to date. To clarify the relationship, their oral condition and sinus of Valsalva (SoV) were evaluated.<br>The subjects were patients with MFS (n = 33) who attended the University of Tokyo Hospital. We divided them into two groups; MFS patients with highly dilated (the diameters were equal to or more than 39 mm) SoV (high group, n = 18) and MFS patients with mildly dilated (less than 39 mm) SoV (mild group, n = 15). Blood examinations, echocardiograms, and full-mouth clinical measurements, including number of teeth, probing pocket depth (PPD), bleeding on probing (BOP), and community periodontal index (CPI) were performed.<br>We found that the high group patients had greater rates of BOP compared to that of the mild group. Furthermore, the high group tended to have higher serum levels of C-reactive protein, matrix metalloproteinase-9, and transforming growth factor-β compared to the mild group.<br>Periodontitis may deteriorate SoV dilatation in MFS patients.</p>
Journal
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- International Heart Journal
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International Heart Journal 57 (4), 456-460, 2016
International Heart Journal Association