Transient changes in serum renalase concentration during long-distance running: The case of an amateur runner under continuous training

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<p>Renalase is a recently discovered flavin adenine dinucleotide (FAD)-dependent soluble monoamine oxidase. It is expressed principally in the kidney, but its expression in the heart, brain, and skeletal muscle has also been confirmed. It is thought that renalase is involved in cardiac function and control of systemic blood pressure primarily by metabolizing circulating catecholamines. Animal experiments have suggested the possibility that exercise is involved in renalase secretion, but this has not been confirmed in human studies. The principal aim of the present study was to investigate the relationship between exercise and renalase concentration in humans. Subjects were young men who were continuously training to run distances of 10-20 km; the total distance that was run in the present study was 30 km. Measurements were performed at four points (before running and after running 10 km, 20 km, and 30 km). The results of one-way analysis of variance examining repeated measurements of serum renalase concentration revealed significant differences (<i>P</i> = 0.007). A significant negative correlation between serum renalase concentration and estimated glomerular filtration rate, which indicates renal function, calculated using serum cystatin C concentration was noted. A significant positive correlation between serum renalase concentration and oxidative stress was observed in the period before exercise and after running 20 km. The present study verified the exercise-induced increase in serum renalase concentration in amateur runners who were continuously training.</p>

収録刊行物

  • JPFSM

    JPFSM 6(3), 159-166, 2017

    一般社団法人日本体力医学会

各種コード

  • NII論文ID(NAID)
    130006907695
  • NII書誌ID(NCID)
    AA12573156
  • 本文言語コード
    ENG
  • ISSN
    2186-8131
  • NDL 記事登録ID
    028200457
  • NDL 請求記号
    Z76-A776
  • データ提供元
    NDL  J-STAGE 
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