IgG4-related Dacryoadenitis and Sialoadenitis Associated with Minor Salivary Gland Swelling; A Case Report

  • KATO Shin
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • ENOKIDA Yohei
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • SATO Hidekazu
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • SHIMIZU Hiroyuki
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • FUJITA Kohei
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • ENDO Tomoki
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • NAKAGAWA Taneaki
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • TSUNODA Kazuyuki
    Department of Dentistry and Oral Surgery, Keio University School of Medicine

Bibliographic Information

Other Title
  • 小唾液腺腫脹を伴ったIgG4関連涙腺・唾液腺炎の1例
  • 症例報告 小唾液腺腫脹を伴ったIgG4関連涙腺・唾液腺炎の1例
  • ショウレイ ホウコク ショウダエキセン シュチョウ オ トモナッタ IgG4 カンレン ルイセン ・ ダエキセンエン ノ 1レイ

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Abstract

Recently Mikulicz’s disease has been considered to be the novel disease entity IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS). We herein report a case of IgG4-DS associated with minor salivary gland swelling. A 26-year-old female complained of bilateral lower lip minor salivary gland, submandibular gland and lacrimal gland swelling. Severe IgG4 positive plasmacyte infiltration was detected in the minor salivary gland, and the serum IgG4 level was markedly elevated. In addition, autoimmune pancreatitis was detected, so the patient was diagnosed with IgG4-DS. IgG4-DS occasionally associates with the minor salivary gland. Therefore, in patients with glandular swelling, IgG4-DS is an important differential diagnosis.

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