腎移植患者における末梢血白血球細胞の遺伝子発現プロファイリングを用いた移植後消化器がんスクリーニング

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  • The use of gene expression profiling of the peripheral blood from kidney transplant recipients in the early detection of digestive system cancer

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<p>【Objective】Kidney transplant recipients are at increased risk of developing cancer in comparison with the general population. To effectively manage post-transplant malignancies, it is essential to proactively monitor patients. A long-term intensive screening program was associated with a reduced incidence of cancer after transplantation. This study evaluated the usefulness of the gene expression profiling of peripheral blood samples obtained kidney transplant patients and adopted a screening test for detecting cancer of the digestive system (gastric, colon, pancreas and biliary tract cancer).<br/> 【Methods】Nineteen patients were included in this study, and a total of fifty-three gene expression screening tests were performed. The gene expression profiles of blood-delivered total RNA and whole genome human gene expression profiles were obtained. We investigated the expression levels of 2,665 genes associated with digestive cancers and counted the number of genes in which expression was altered. A hierarchical clustering analysis was also performed. The final prediction of the cancer possibility was determined according to an algorithm.<br/> 【Results】The number of genes in which expression was altered was significantly increased in the kidney transplant recipients in comparison to the general population (1,091±63 vs. 823±94, p=0.0024). The number of genes with altered expression decreased after the induction of mTOR inhibitor (1,484±227 vs. 883±154, p=0.0439). No cases of possible digestive cancer were detected in this study period.<br/> 【Conclusion】The gene expression profiling of peripheral blood samples may be a useful and non-invasive diagnostic tool that allows for the early detection of cancer of the digestive system.</p>

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  • 移植

    移植 51 (6), 470-476, 2016

    一般社団法人 日本移植学会

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