Effect of Newly-developed Bioactive Glass Root Canal Sealer on Periapical Tissue of Rat's Molar

DOI Open Access
  • Takahiko MOROTOMI
    Division of Endodontics and Restorative Dentistry, Department of Science of Oral Functions, Kyushu Dental University
  • Kaori HANADA
    Division of Endodontics and Restorative Dentistry, Department of Science of Oral Functions, Kyushu Dental University
  • Ayako WASHIO
    Division of Endodontics and Restorative Dentistry, Department of Science of Oral Functions, Kyushu Dental University
  • Shinji YOSHII
    Division of Endodontics and Restorative Dentistry, Department of Science of Oral Functions, Kyushu Dental University
  • Kou MATSUO
    Division of Oral Pathology, Department of Health Promotion, Kyushu Dental University
  • Chiaki KITAMURA
    Division of Endodontics and Restorative Dentistry, Department of Science of Oral Functions, Kyushu Dental University

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Other Title
  • 新規バイオガラス配合根管充塡用シーラーのラット臼歯根尖歯周組織に対する影響

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Abstract

<p> Purpose: Although many properties are required for root canal sealer, no sealer satisfies all of them at present. We aimed to develop a novel root canal sealer with ideal properties, such as high capacity of sealing and removability, ease of use, and high biocompatibility. In the present study, newly developed bioactive glass based root canal sealer (BG sealer) and zinc oxide non-eugenol based sealer (NE-Z sealer) were histopathologically evaluated by means of a rat model for pulpectomy and root canal obturation.</p><p> Method: Distal root canals of mandibular first molars of post-natal 7-week-old male Wistar rats were shaped and prepared. After drying with paper point following root canal irrigation with EDTA solution, sodium hypochlorite solution, and saline, canals were filled with either BG sealer or NE-Z sealer. After 1 and 3 weeks, mandibles were dissected, serial paraffin sections were prepared, and then periapical tissues were examined histopathologically.</p><p> Results: One week after obturation, apparent inflammatory cell infiltration was observed in periapical tissues of both groups, and the inflammatory response decreased at 3 weeks after obturation. Next, the width of periapical alveolar bone resorption area and the thickness of cementum at the root apex were analyzed. No significant difference of periapical alveolar bone resorption area was observed in both groups at 1 and 3 weeks, whereas the width of the area significantly reduced from 1 week to 3 weeks when canals were filled with BG sealer. Cementum in the periapical region of the BG sealer group was significantly thicker than that in the NE-Z sealer group. The thickness of cementum in the BG sealer group significantly increased from 1 week to 3 weeks, but not in the NE-Z sealer group.</p><p> Conclusion: The present in vivo results from the rat model suggest that the newly developed BG sealer is biocompatible with periapical tissues.</p>

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