Analysis of secretory lipolytic enzyme activities in <I>Malassezia</I>

• ジャンタチャイ ウィーラポン

  東京工業大学 大学院生命理工学研究科 分子生命科学専攻

• 大浦 隆宏

  東京工業大学 大学院生命理工学研究科 分子生命科学専攻

• 村山 〓明

  北里大学 北里生命科学研究所＆大学院感染制御科学府感染制御・免疫学部門 病原微生物分子疫学研究室

• 梶原 将

  東京工業大学 大学院生命理工学研究科 分子生命科学専攻

抄録

Malassezia yeasts are cutaneous microflora commonly found in animals and human and sometimes cause various opportunistic skin diseases. As most of Malassezia species are lipid-dependent, lipolytic enzymes are necessary for them to obtain lipids from the environment and then lipase and phospholipase which degrade neutral lipids and phospholipids, respectively, are thought to play an important role for growth and pathogenicity of Malassezia. Here we investigated a common culture condition for several Malassezia spp. and these secretory lipase and phospholipase activities comparably. Interestingly, lipase and phospholipase activities in M. globosa strains revealed the highest values in the lipid-dependent Malassezia spp.. M. globosa also showed higher activities of these lipolytic enzymes than M. pachydermatis known to possess high phospholipase activity. From these results, it was supposed that secretory lipase and phospholipase activities relate to the dominant survival of M. globosa found in many patients.

収録刊行物

• 日本医真菌学会総会プログラム・抄録集

  日本医真菌学会総会プログラム・抄録集 51 (0), 125-125, 2007

  日本医真菌学会

詳細情報

• CRID: 1390282680500675840
• NII論文ID: 130006948241
• DOI: 10.11534/jsmm.51.0.125.0
• ISSN: 09164804
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可