Thymic Transplantation:  Attempt to extend thymus-dependent tolerance-inducing protocols to adult patient populations

山田 和彦

doi:10.14906/jscisho.36.0.36.0

The thymus, the site of origin of T cell immunity, shapes the repertoire of T cell reactivity through positive selection of developing T cells and prevents autoimmunity through negative selection of autoreactive T cells. Previous our studies have demonstrated an important role for the host thymus in the induction of transplant tolerance across allogeneic barriers in MHC inbred miniature swine. The same protocol did not induce tolerance in thymectomized recipients nor in recipients beyond the age of thymic involution. We subsequently reported that vascularized thymic lobe (VTL) grafts from juvenile donors were capable of inducing tolerance across fully allogeneic barriers in thymectomized hosts. In addition, we have extended this VTL strategy to a xenogeneic model and reported longer than 80 days survival of GalT-KO pig kidneys with stable renal function in baboons when juvenile donor vascularized thymis grafts were cotransplanted. However, the important question remained whether aged, involuted thymus could also induce tolerance. In this symposium, I will introduce our data including out preliminary data on medical thymic regeneration. Our attempts could have practical implications for extending thymus-dependent tolerance-inducing protocols to adult patient populations.

Thymic Transplantation: Attempt to extend thymus-dependent tolerance-inducing protocols to adult patient populations

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