セシウムエノラートの分子内 ipso 置換を経由する5, 4'-二置換型フラボン類の効率的合成
書誌事項
- タイトル別名
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- An effective synthesis of 5, 4'-disubstituted flavones via a cesium enolate assisted intramolecular ipso-substitution reaction
抄録
A variety of 5,4'-disubstituted flavones, which are anticipated to be androgen receptor antagonists to treat diseases mediated by the androgen receptor, were synthesized. It was found that an intramolecular ipso-substitution reaction via cesium enolate using 2-fluoro-6-hydroxyacetophenone and various benzoyl chlorides was effective in the preparation of 5-hydroxy-4'-alkylflavones.
収録刊行物
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- 反応と合成の進歩シンポジウム 発表要旨概要
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反応と合成の進歩シンポジウム 発表要旨概要 37 (0), 150-150, 2011
日本薬学会化学系薬学部会
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詳細情報
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- CRID
- 1390282680610648576
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- NII論文ID
- 130006996127
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可