セシウムエノラートの分子内 ipso 置換を経由する5, 4'-二置換型フラボン類の効率的合成

DOI

書誌事項

タイトル別名
  • An effective synthesis of 5, 4'-disubstituted flavones via a cesium enolate assisted intramolecular ipso-substitution reaction

抄録

A variety of 5,4'-disubstituted flavones, which are anticipated to be androgen receptor antagonists to treat diseases mediated by the androgen receptor, were synthesized. It was found that an intramolecular ipso-substitution reaction via cesium enolate using 2-fluoro-6-hydroxyacetophenone and various benzoyl chlorides was effective in the preparation of 5-hydroxy-4'-alkylflavones.

収録刊行物

詳細情報

  • CRID
    1390282680610648576
  • NII論文ID
    130006996127
  • DOI
    10.14895/hannou.37.0.150.0
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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