アンチWacker 型環化反応による２，３－二置換インデノールの合成法
書誌事項
- タイトル別名
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- Synthesis of 2,3-Disubstituted Indenols via Palladium(0)-Catalyzed 'Anti-Wacker'-Type Cyclization
抄録
Indenols can be synthesized by aryl, alkenyl, and alkylative cyclization of 2-ethynylbenzaldehydes with organoboronic reagents via palladium(0)-catalyzed 'anti-Wacker'- type oxidation addition. This method is suitable for their combitatorial synthesis due to not only facile preparation of 2-ethynylbenzaldehydes from 2-halobenzaldehydes and terminal alkynes by the Sonogashira reaction but also availability of the boronic reagents. The trans-addition of intramolecur electrophilic carbonyls and boronic reagents to the alkyne is enhanced by aryl and alkenyl substitutions at the terminal alkyne carbon. In comparison with other transition-metal catalyzed preparation of indenols from 2-halobenzaldehydes or 2-formylphenylboronic acids with internal alkynes, our procedure enables to introduce sterically and electronically similar two substituents at 2- and 3- positions in regioselective manner.
収録刊行物
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- 反応と合成の進歩シンポジウム 発表要旨概要
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反応と合成の進歩シンポジウム 発表要旨概要 32 (0), 20-20, 2006
日本薬学会化学系薬学部会
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詳細情報 詳細情報について
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- CRID
- 1390282680610972544
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- NII論文ID
- 130006996515
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 使用不可