ケイ素反応剤－ルイス塩基触媒系によるアジリジンの新規開環反応

• 南方 聖司

  阪大院工

• 岡田 有理子

  阪大院工

• 日高 生允

  阪大院工

• 大平落 洋二

  阪大院工

• 小松 満男

  阪大院工

書誌事項

タイトル別名

• Lewis Base Catalyzed Ring Opening of Aziridines with Silylated Nucleophiles

抄録

We have already revealed new methods for aziridination of olefins with Chloramine-T as a nitrogen source. In order to clarify a potential utility of aziridines, their catalytic ring opening reactions are investigated by using the combination of trimethylsilyl cyanide and commercially available Lewis bases. Among these, a tertiary amine such as tetramethylethylenediamine (TMEDA) was found to be a good catalyst to afford regioselective ring opening products. The amine-catalyzed ring opening of aziridines with TMSCN is applicable to other silylated nucleophiles, TMSN3, and TMSX (X = Br, I) . A variety of aziridines were efficiently opened with silylated nucleophiles in the presence of TMEDA catalyst.

収録刊行物

• 反応と合成の進歩シンポジウム 発表要旨概要

  反応と合成の進歩シンポジウム 発表要旨概要 31 (0), 114-114, 2005

  日本薬学会化学系薬学部会

キーワード

• ring opening of aziridines
• silicon reagents
• Lewis bases,
• regioselectivity

詳細情報

• CRID: 1390282680611321600
• NII論文ID: 130006997024
• DOI: 10.14895/hannou.31.0.114.0
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可