二重活性化機構を有する二核バナジウム触媒の開発とエナンチオ選択的反応への応用 Dual Activation in a Homolytic Coupling Reaction Promoted by an Enantioselective Dinuclear Vanadium(IV) Catalyst

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Abstract

A new concept of dual activation catalysis for the enantioselective homolytic coupling reaction of 2-naphthol derivatives is described. The novel dinuclear vanadium(IV) complexes, bearing two active metal sites attached to the 3,3'-position on binaphthyl, biphenyl and octahydro binaphthyl skeletons, promote the oxidative coupling reaction of 2-naphthols to afford BINOL derivatives in good yield with up to 94% ee. This “dual activation” mechanism was supported by kinetic analysis of the catalytic reaction and the effect of catalyst loading.

Journal

  • Proceedings of the Symposium on Progress in Organic Reactions and Syntheses

    Proceedings of the Symposium on Progress in Organic Reactions and Syntheses 30(0), 214-215, 2004

    Division of Organic Chemistry, The Pharmaceutical Society of Japan

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