Development of a Novel Sugar Linkage: 6, 6'-Ether-Connected Sugars

• Takahashi Hideyo

  Faculty of Pharmaceutical Sciences, Teikyo University

• Fukuda Toshimitsu

  Faculty of Pharmaceutical Sciences, Teikyo University

• Mitsuzuka Haruhiko

  Faculty of Pharmaceutical Sciences, Teikyo University

• Nishiyama Kazusa

  Faculty of Pharmaceutical Sciences, Teikyo University

• Ikegami Shiro

  Faculty of Pharmaceutical Sciences, Teikyo University

Bibliographic Information

Other Title

• 新規なエーテル結合糖の合成

Abstract

In 1997, coyolosa was isolated from the Acrocomia mexicana root. It is worth noting that coyolosa, which is a new carbohydrate connected by an ether-linkage, shows a significant effect on the fasting blood glucose level. So far, no studies on the sugar linkage by ether bonding have ever been reported. Thus, we examined a novel synthesis of 6,6'-ether-connected pyranoses. Also, we reconsidered the proposed structure of coyolosa based on the structure–activity relationship (SAR) studies.

Journal

• Proceedings of the Symposium on Progress in Organic Reactions and Syntheses

  Proceedings of the Symposium on Progress in Organic Reactions and Syntheses 30 (0), 248-249, 2004

  Division of Organic Chemistry, The Pharmaceutical Society of Japan

Keywords

• coyolosa
• hypoglycemic activity
• ether-linked sugar
• reductive etherification
• acetal

Details

• CRID: 1390282680611593728
• NII Article ID: 130006997354
• DOI: 10.14895/hannou.30.0.248.0
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed