クラブバイサイクロンの不斉合成研究
書誌事項
- タイトル別名
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- Study of Enantioselective Synthesis of Clavubicyclone
抄録
Clavubicyclone was isolated from Okinawan soft coral, Clavularia viridis, by our group as a novel prostanoid-related compound. The absolute stereochemistry and biological activity of clavubicyclone have not yet been examined due to small quantities of isolated samples. We recently achieved the total synthesis of clavubicyclone as a racemic form through Cope rearrangement as a key step. However, there are several problems on our previous synthetic route; improvement of the yield of Cope rearrangement and shortening of the relatively longer sequence. To overcome these problems and to achieve an enantioselective synthesis, we examined further synthetic research. Cope rearrangement was proceeded smoothly by changing the stereochemistry of the substrate. We also achieved to obtain an intermediate as an optically active form by using enantioselective Mukaiyama aldol reaction. Introduction of side chains to an optically active bicyclo[3.2.1]octane skeleton is now underway.
収録刊行物
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- 反応と合成の進歩シンポジウム 発表要旨概要
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反応と合成の進歩シンポジウム 発表要旨概要 34 (0), 144-144, 2008
日本薬学会化学系薬学部会
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詳細情報 詳細情報について
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- CRID
- 1390282680612907904
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- NII論文ID
- 130006998866
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可