The effects of photon or heavy ion on the processes of metastasis and angiogenesis

DOI

Bibliographic Information

Other Title
  • 光子線と重粒子線によるがんの転移過程と血管新生に及ぼす影響

Abstract

The purpose of this study was to compare metastatic capabilities of malignant tumor cells and angiogenesis after irradiation with photon and carbon-ion beams to clarify heavy ion beam-specific biological effects. Several authors have reported that sublethal photon irradiation may potentiate metastatic ability of irradiated cancer cells. We examined the biological properties of highly aggressive HT1080 human fibrosarcoma cells and HUVEC human umbilical vascular endothelial cells to assess their metastatic processes and angiogenesis in vitro. We then assessed the metastatic capabilities of LM8 mouse osteosarcoma irradiated with carbon-ion and photon beam in the syngeneic mice. Our study found that carbon-ion irradiation decreased cancer cell migration, invasion in a dose-dependent manner and strongly inhibited MMP-2 (matrix metalloproteinase-2) activity in vitro. The capillary-like tube structure in three-dimensional culture of endothelial cells was inhibited significantly by carbon-ion irradiation in a dose-dependent manner. In vivo, treatment with carbon-ion reduced the number of lung metastases in a dose-dependent manner. On the other hand, lower X-ray irradiation facilitated cell migration and invasion concomitant with up-regulation of αVβ3 integrin in vitro. These findings provide preclinical rationales that heavy ion radiotherapy may be superior to conventional photon beam therapy in possible preventive effects on metastases of irradiated malignant tumor cells and angiogenesis.

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Details 詳細情報について

  • CRID
    1390001205639842944
  • NII Article ID
    130006999721
  • DOI
    10.11513/jrrsabst.2008.0.52.0
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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