Expression of endothelin-1 in gingival epithelial cells
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- Yamamoto Eri
- Department of Preventive Dentistry, Kyushu Dental College
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- Awano Shuji
- Department of Preventive Dentistry, Kyushu Dental College
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- Koseki Takeyoshi
- Department of Preventive Dentistry, Kyushu Dental College
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- Ansai Toshihiro
- Department of Preventive Dentistry, Kyushu Dental College
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- Takehara Tadamichi
- Department of Preventive Dentistry, Kyushu Dental College
Bibliographic Information
- Other Title
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- 歯肉上皮細胞におけるエンドセリン1の発現
Abstract
The present study aimed to clarify a hypothesis that endothelin-1 (ET-1) would relate to the inflammation of periodontium, so that ET-1 presence and location in human gingival tissues and the ET-1 expression of KB cells were examined. As a result of immunohistochemistry of human gingival tissue sections, the expression of ET-1 in inflamed gingival tissues was increasing in the gingival epithelial cells and vascular endothelial cells compared to uninflamed tissues. After KB cells were cultured with P. gingivalis, the expression of ET-1 was examined using RT-PCR and ELISA. Compared to KB cells cultured without P. gingivalis, ET-1 mRNA levels of the KB cells and ET-1 protein expression in the supernatants were significantly greater in the cells with P. gingivalis. The present study indicated that ET-1 was increasing in inflamed periodontal tissues, therefore, it was suggested that ET-1 expression in the gingival epithelial cell associated with the inflammation of periodntium.
Journal
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- Program and Abstracts of the Annual Meeting of the Kyushu Dental Society
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Program and Abstracts of the Annual Meeting of the Kyushu Dental Society kds62 (0), 21-21, 2002
KYUSHU DENTAL SOCIETY
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Details 詳細情報について
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- CRID
- 1390001205711778560
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- NII Article ID
- 130007021895
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed