カロリー制限模倣物質レスベラトロールによる脂肪細胞でのレジスチン遺伝子発現抑制

• 井原 勇人

  浜松医科大学・医・生理学第二

• 浦野 哲盟

  浜松医科大学・医・生理学第二

書誌事項

タイトル別名

• A caloric restriction mimetic, resveratrol-mediated transcriptional repression of resistin gene in 3T3-L1 adipocytes.

抄録

Resistin is a newly identified as a cysteine-rich adipose tissue-specific secretory adipokine that may link obesity and insulin resistance. We have studied the effect of resveratrol, a phytoalexne stilbene from grapes, on the regulation of resistin gene expression during 3T3-L1 adipogenesis. Resveratrol treatments attenuated adipocyte differentiation, which resulted in a dramatic decrease in resistin mRNA levels as well as its protein levels secreted into the culture medium in a dose-dependent fashion. In contrast, epigaro-catechin-3-gallate, a main polyphenoric compound of green tea leaf which has antioxidant potency same as resveratrol, did not repress resistin gene expression in the same dose-range. Transient transfection experiments with resistin promoter/luciferase reporter revealed that resveratrol reduced transcriptional activity of the resistin gene in a dose-dependent manner. These results indicate that the resistin gene expression is down-regulated by resveratrol through the reduction of gene transcription in 3T3-L1 adipocytes. [J Physiol Sci. 2007;57 Suppl:S89]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2007 (0), 089-089, 2007

  一般社団法人　日本生理学会

キーワード

• Resistin
• Resveratrol
• Caloric restriction
• Adipokine

詳細情報

• CRID: 1390282680704233472
• NII論文ID: 130007038690
• DOI: 10.14849/psjproc.2007.0.089.1
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可