神経ネットワークと微小循環のダイナミクス:大脳半球間相互作用と神経活動・微小循環のカップリング

• 根本 正史

  東京都精神医学総合研究所・脳機能解析研究チーム

• 星 詳子

  東京都精神医学総合研究所・脳機能解析研究チーム

• 佐藤 知絵

  東京都精神医学総合研究所・脳機能解析研究チーム

• 寺川 進

  浜松医科大学・光量子医学研究センター

書誌事項

タイトル別名

• The dynamics of neural network and microcirculation: interhemispheric interactions and neurovascular coupling

抄録

Interhemispheric neural interactions between bilateral cortical regions are critically dependent on interhemispheric time lag of cortical activation. In somatosensory systems the time lag information is processed for integrating bilateral stimulus inputs. Here we investigated interhemispheric interactions between bilateral somatosensory cortices by simultaneous recording of neural and hemodynamic signals and by analyzing their dependence on stimulus time lag between conditioning stimuli (CS) and test stimuli (TS). We measured electrophysiological signals (local field potentials, 1<LFPs<100 Hz; multiunit spiking activity, 300<MUA<5k Hz) and optical intrinsic signals (586 nm, cerebral blood volume, CBV; 605 nm, oxygenation) in rat somatosensory cortex evoked by electrical pulses to the contralateral hindpaw (TS) while delivering electrical pulses to the ipsilateral hindpaw (CS) under α-chloralose anesthesia. Both responses to CS-TS were normalized by the responses to TS without CS. The results showed that both electrophysiological (LFPs and MUA) and optical (586 nm monophasic and 605 nm biphasic activity) responses were significantly suppressed around 40-60 ms time lag and slightly augmented at 0 ms. Average and trial-by-trial correlation analyses revealed that CBV-related optical signals have high fidelity to integrated MUA and LFP negative components. Activity-related microcirculatory responses may more faithfully reflect neural interactions through brain network than we imagined. [J Physiol Sci. 2006;56 Suppl:S90]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2006 (0), 090-090, 2006

  一般社団法人　日本生理学会

キーワード

• neuronal activity
• cerebral blood volume
• optical imaging
• interhemispheric interaction
• neurovascular coupling

詳細情報

• CRID: 1390282680705012608
• NII論文ID: 130007039024
• DOI: 10.14849/psjproc.2006.0.090.1
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可