低酸素刺激によるモルモット胃平滑筋の自発電気活動及び自律神経反応の変化

• 中村 江里

  名古屋市立大学・医学研究科・細胞機能制御学

• 横井 剛

  名古屋市立大学・医学研究科・細胞機能制御学

• 鈴木 光

  名古屋市立大学・医学研究科・細胞機能制御学

書誌事項

タイトル別名

• Effects of hypoxia on spontaneous electrical activity and its autonomic neuronal modulation in smooth muscle tissues isolated from the guinea-pig stomach

抄録

Gastric smooth muscle generates slow waves spontaneously, and they are regulated by autonomic nerves. Experiments were carried out to investigate the effects of hypoxia on spontaneous electrical activity and their autonomic neuronal regulation in smooth muscle of the guinea-pig stomach. Segments of smooth muscle tissues were isolated from the antrum region of the stomach, and electrical activities of smooth muscle cells were recorded using conventional microelectrode technique. Junction potentials produced by transmural nerve stimulation were also recorded. Isometric mechanical responses of smooth muscle tissue were also examined. Low oxygen condition, produced by bubbling with N₂-gasses, induced a reduction in resting tension, spontaneous rhythmic contractions and mechanical responses produced by nerve stimulation, with no significant alteration to the frequency of spontaneous contraction. These changes were not associated with change in electrical responses of the membrane (the resting membrane potential, shape of slow waves and junction potentials). Acetylcholine (Ach)-induced depolarization and contraction responses were also not changed significantly during hypoxia. The results suggest that oxygen requirement for mitochondrial activity responsible for production of rhythmic activity is relatively low. [Jpn J Physiol 55 Suppl:S118 (2005)]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2005 (0), S118-S118, 2005

  一般社団法人　日本生理学会

キーワード

• smooth muscle
• slow wave
• hypoxia

詳細情報

• CRID: 1390282680705811840
• NII論文ID: 130007039080
• DOI: 10.14849/psjproc.2005.0.s118.1
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可