Attenuation of osmotic- and angiotensin-induced water intake with estrogen replacement and c-Fos expression in ovariectomized rats

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Other Title
  • エストロゲン補充が卵巣摘出ラットの飲水行動に及ぼす影響と視床下部における<I>c-fos</I>発現

Abstract

We examined the effect of estradiol replacement in ovariectomized rats on water intake and hypothalamic c-Fos expression in response to plasma hyperosmolality and central angiotensin II (ANGII) administration. Ovariectomized rats were assigned into estradiol-(E2-T) and placebo(Pla-T)-treated groups. Two weeks after the ovariectomy, rats were infused with hypertonic saline (1.5 M; 0.33 ml/100g/BW; i.v.). Access to water was provided 10-min after the infusion and water intake was measured for 30 min. A few days later, c-Fos expression in response to the osmotic challenge was examined immunohistochemically. The same protocols were employed in other rats to examine the responses of water intake and c-Fos expression to central ANGII injection (5ng; i.c.v.). E2-T rats drank less water than Pla-T rats in response to both plasma hyperosmolality and central ANGII. The number of c-Fos ir cells in the OVLT in response to either osmotic or ANGII stimulations was not different between two groups. The number of c-Fos ir cells in the lateral part of the PVN after osmotic challenge in E2-T was lower than Pla-T group. In addition, E2 treatment decreased AngII-induced c-Fos expression in the SFO and the SON as compared to placebo treatment. Thus, estrogen attenuates osmoregulatory water intake, and the central ANGII might be involved in this action. The location of estrogen action might be on the pathway between the osmoreceptors and hypothalamic nuclei related to body fluid regulation. [Jpn J Physiol 55 Suppl:S199 (2005)]

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Details 詳細情報について

  • CRID
    1390282680705968896
  • NII Article ID
    130007039144
  • DOI
    10.14849/psjproc.2005.0.s199.1
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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