栄養素摂取によって引き起こされるマウス肝臓時計遺伝子発現リズム

• 平尾 彰子

  Lab.of Physiol. and Phar. Sch. of Adv. Science and Engineering, Waseda University, Tokyo202-0021, Japan.

• 田原 優

  Lab.of Physiol. and Phar. Sch. of Adv. Science and Engineering, Waseda University, Tokyo202-0021, Japan.

• 井筒 裕之

  Lab.of Physiol. and Phar. Sch. of Adv. Science and Engineering, Waseda University, Tokyo202-0021, Japan.

• 本間 さと

  Department of Physiolosy, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan

• 本間 研一

  Department of Physiolosy, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan

• 柴田 重信

  Lab.of Physiol. and Phar. Sch. of Adv. Science and Engineering, Waseda University, Tokyo202-0021, Japan.

書誌事項

タイトル別名

• Nutritional analysis of food-entrained oscillation in the mouse liver

抄録

Daily restricted feeding (RF) with fixed time during daytime causes an advance of circadian rhythm of mouse liver clock gene expression. However, the mechanism of entrainment signal is poorly understood. Here, we examine whether daily administration of various type of nutrition caused entrainment of liver clock gene expression rhythm using Bmal1-luciferase transgenic mouse. Circadian rhythm change of liver bioluminescence was recorded through Lumicycle after 1-6 days of administration of various nutrients. We administered the corn carbon dehydrate, egg albumin or soybean oil after adjustment of each calorie. Among these nutrients soybean oil has most strong effect on phase-shift of gene expression rhythm. Administration of glucose through oral or intraperitoneal caused the phase advance, however the value of change was small. Thus, slow supply of calorie may be important to cause phase shift. We still examine the other nutrients such as amino acids, dextrin and sugar. We also try to find the effect of combination of nutrients on phase-shift of liver clock. [J Physiol Sci. 2008;58 Suppl:S198]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2008 (0), 198-198, 2008

  一般社団法人　日本生理学会

キーワード

• Nutrition
• liver
• circadian

詳細情報

• CRID: 1390001205729301632
• NII論文ID: 130007039203
• DOI: 10.14849/psjproc.2008.0.198.1
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可