動的粘弾性 OCSA を用いた軟骨変性力学診断法の基礎的検討

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  • Fundamental study on mechanical diagnosis of cartilage degeneration using Dynamic Mechanical Analyzing Optical Coherence Straingraphy

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<p>Many of the elderly are predisposed to develop osteoarthritis (OA), although it is quite difficult to diagnose the earlygrade OA even by latest imaging modalities. In this study, we have proposed Dynamic Mechanical Analyzing Optical Coherence Straingraphy, namely DMA-OCSA, which is a tomographically micro-visualizing method of visco-elastic properties estimated from continuous OCT images. This is based on the speckle tracking algorithm having high sensitivity and S/N under micrometer resolution, thus can provide temporal and spatial distribution of not only deformation velocity but also strain rate during a dynamic visco-elasticity test. This was experimentally applied to comparatively both normal cartilages and cartilages degenerated by the collagenase enzyme treatment. Consequently, the sinusoidal time-varying strain rate was locally observed to have phase difference between the superficial tangential zone and middle zone, which could cause degradation of visco-elasticity.</p>

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  • 年次大会

    年次大会 2016 (0), S0220103-, 2016

    一般社団法人 日本機械学会

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