Experimental combined hormone therapy on human breast carcinomas serially transplanted into nude mice.
-
- FUKUTOMI Takashi
- Department of Surgery, School of Medicine, Keio University
-
- KUBOTA Tetsuro
- Department of Surgery, School of Medicine, Keio University
-
- IKEDA Tadashi
- Department of Surgery, School of Medicine, Keio University
-
- ISOBE Yoh
- Department of Surgery, School of Medicine, Keio University
-
- KIKUYAMA Shigehiro
- Department of Surgery, School of Medicine, Keio University
-
- SHIMADA Akihiko
- Department of Surgery, School of Medicine, Keio University
-
- NAKAMURA Akihiko
- Department of Surgery, School of Medicine, Keio University
-
- NISHIUMI Takao
- Department of Surgery, School of Medicine, Keio University
-
- ENOMOTO Kohji
- Department of Surgery, School of Medicine, Keio University
-
- ISHIBIKI Kyuya
- Department of Surgery, School of Medicine, Keio University
-
- ABE Osahiko
- Department of Surgery, School of Medicine, Keio University
Abstract
Experimental combined hormone therapy with tamoxifen, aminoglutethimide and medroxyprogesterone acetate was investigated using three hormone-dependent human breast carcinomas serially transplanted into nude mice. The antitumor effect of combined tamoxifen and aminoglutethimide was better than that of either tamoxifen or aminoglutethimide alone. Since aminoglutethimide significantly reduced the level of estrogen and the uterine weight in normal female mice, the antitumor effect of combined tamoxifen and aminoglutethimide was assumed to be a result of the low estrogen level produced by aminoglutethimide, favoring the competition of tamoxifen with estrogen receptors. There was no additive antitumor effect of the combination of tamoxifen and medroxyprogesterone acetate, although serum medroxy-progesterone acetate levels in nude mice were almost equivalent to those of humans. These results indicate that combination hormone therapy, especially with tamoxifen and aminoglutethimide, might be a promising method for clinical application.
Journal
-
- Japanese Journal of Cancer Research GANN
-
Japanese Journal of Cancer Research GANN 77 (1), 92-97, 1986
The Japanese Cancer Association
- Tweet
Details 詳細情報について
-
- CRID
- 1571135653245817088
-
- NII Article ID
- 130007310120
-
- Text Lang
- en
-
- Data Source
-
- CiNii Articles