Plasma endotoxin activity in Eastern grey kangaroos (<i>Macropus giganteus</i>) with lumpy jaw disease

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  • SOTOHIRA Yukari
    School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan Itozu no mori Zoological Park, 4-1-8 Kamiitozu, Kokurakita, Kitakyushu, Fukuoka 803-0845, Japan
  • SUZUKI Kazuyuki
    School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
  • OTSUKA Marina
    School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
  • TSUCHIYA Masakazu
    Endotoxin and Microbial Detection, Charles River, 1023 Wappoo Road, Suite 43B, Charleston, SC 29407, U.S.A.
  • SHIMAMORI Toshio
    School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
  • NISHI Yasunobu
    School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
  • TSUKANO Kenji
    School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
  • ASAKAWA Mitsuhiko
    School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan

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  • Plasma endotoxin activity in Eastern grey kangaroos (Macropus giganteus) with lumpy jaw disease

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Abstract

<p>Progressive pyogranulomatous osteomyelitis involving the mandible or maxilla of captive macropods, referred to as “Lumpy jaw disease (LJD)”, is one of the most significant causes of illness and death in captive macropods. The aim of the present study was to evaluate the relationship between the severity of LJD and plasma endotoxin activity in kangaroos. Plasma samples obtained from moderate (n=24) and severe LJD (n=12), and healthy kangaroos (n=46), were diluted 1:20 in endotoxin-free water and heated to 80°C for 10 min. Plasma endotoxin activity was measured using the Limulus amebocyte lysate (LAL)-kinetic turbidimetric (KT) assay. Plasma endotoxin activity was higher in kangaroos with severe LJD (0.199 ± 0.157 EU/ml) than in those with moderate LJD (0.051 ± 0.012 EU/ml, P<0.001) and healthy controls (0.057 ± 0.028 EU/ml, P<0.001). Our results suggest that the severity of LJD in captive macropods may be related to the plasma endotoxin activity.</p>

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