Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma
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- ADACHI Mami
- Laboratory of Advanced Veterinary Medicine, Department of Veterinary Clinical Sciences, Hokkaido University, Hokkaido 060–0818, Japan
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- HOSHINO Yuki
- Veterinary Teaching Hospital, Hokkaido University, Hokkaido 060–0818, Japan
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- IZUMI Yusuke
- Laboratory of Advanced Veterinary Medicine, Department of Veterinary Clinical Sciences, Hokkaido University, Hokkaido 060–0818, Japan
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- TAKAGI Satoshi
- Veterinary Teaching Hospital, Hokkaido University, Hokkaido 060–0818, Japan
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抄録
Canine hemangiosarcoma (HSA) is a progressive malignant neoplasm of dogs for which there is currently no effective treatment. A recent study suggested that receptor tyrosine kinases (RTKs), the PI3K/Akt/m-TOR and MAPK pathways are all activated in canine and human HSA. The aim of the present study was to investigate the overexpression of these proteins by immunohistochemistry in canine splenic HSA to identify potential molecular therapeutic targets. A total of 10 splenic HSAs and two normal splenic samples surgically resected from dogs were sectioned and stained with hematoxylin and eosin for histological diagnosis or analyzed using immunohistochemistry. The expression of RTKs, c-kit, VEGFR-2 and PDGFR-2, as well as PI3K/Akt/m-TOR and MEK was higher in canine splenic HSAs compared to normal spleens. These proteins may therefore be potential therapeutic targets in canine splenic HSA.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 78 (4), 649-656, 2016
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206431217280
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- NII論文ID
- 130007331498
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- NII書誌ID
- AA11510037
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- ISSN
- 13477439
- 09167250
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- HANDLE
- 2115/62286
- 10659/00005380
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- NDL書誌ID
- 027341595
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- PubMed
- 26685984
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可