Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
Access this Article
Search this Article
Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma.
- Journal of Veterinary Medical Science
Journal of Veterinary Medical Science 78(4), 685-689, 2016
JAPANESE SOCIETY OF VETERINARY SCIENCE