Preoperative peripheral blood lymphocyte-to-monocyte ratio is a prognostic indicator in oral squamous cell carcinoma: a retrospective study in a single institution

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  • WATABE Yukio
    Department of Oral and Maxillofacial surgery, Tokyo Dental College Department of Dentistry and Oral Surgery, Tokyo Metropolitan Tama Medical Center
  • ONIDANI Kaoru
    Department of Oral and Maxillofacial surgery, Tokyo Dental College
  • MATSUMOTO Nobuhiko
    Department of Oral and Maxillofacial surgery, Tokyo Dental College
  • HAYASHI Kamichika
    Department of Oral and Maxillofacial surgery, Tokyo Dental College
  • MORIKAWA Takamichi
    Department of Oral and Maxillofacial surgery, Tokyo Dental College
  • ONDA Takeshi
    Department of Oral and Maxillofacial surgery, Tokyo Dental College
  • YAKUSHIJI Takashi
    Department of Oral and Maxillofacial surgery, Tokyo Dental College
  • OHATA Hitoshi
    Department of Oral and Maxillofacial surgery, Tokyo Dental College
  • TAKANO Nobuo
    Department of Oral and Maxillofacial surgery, Tokyo Dental College Oral Cancer Center, Tokyo Dental College
  • SHIBAHARA Takahiko
    Department of Oral and Maxillofacial surgery, Tokyo Dental College Oral Cancer Center, Tokyo Dental College

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Other Title
  • 口腔扁平上皮癌の予後予測における術前末梢血リンパ球数・単球数比の有用性に関する単施設後ろ向き研究
  • コウコウ ヘンペイ ジョウヒ ガン ノ ヨゴ ヨソク ニ オケル ジュツゼン マッショウケツ リンパキュウスウ ・ タンキュウスウヒ ノ ユウヨウセイ ニ カンスル タンシセツ ウシロ ムキ ケンキュウ

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Abstract

<p>Although lymphocyte-to-monocyte ratio (LMR) has been shown to be a prognostic indicator in various cancers, the prognostic value of preoperative LMR in patients with oral squamous cell carcinoma has not been reported. The aim of this study was to evaluate whether preoperative LMR could predict the outcomes of patients with oral squamous cell carcinoma. We studied 210 patients who underwent curative surgery for oral squamous cell carcinoma in Tokyo Dental College, Chiba Hospital between January 2007 and December 2011. LMR was calculated from the preoperative peripheral blood cell counts. The optimal cutoff point of LMR was determined on the basis of a time-dependent receiver operating characteristics curve for overall survival. A total of 94 patients met the inclusion criteria. The low LMR group had a significantly lower survival rate than the high LMR group (p= 9.44 × 10-11, log-rank test). Univariate analysis using a Cox proportional-hazards model showed that N classification, disease stage, and pretreatment LMR were significantly associated with poor outcomes. Multivariate analysis showed that pretreatment LMR (hazard ratio ［HR］: 0.07; 95% confidence interval ［CI］: 0.01-0.37, p= 2.12×10-3) remained as a risk factor for cancerrelated death. Thus, pretreatment LMR might be an independent prognostic biomarker in patients with oral squamous cell carcinoma.</p>

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