Transdermal Drug Delivery System Utilizing Ionic Liquids

DOI Web Site Web Site Open Access
  • Wakabayashi Rie
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University Advanced Transdermal Drug Delivery System Center, Kyushu University
  • Kozaka Shuto
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • Goto Masahiro
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University Center for Future Chemistry, Kyushu University Advanced Transdermal Drug Delivery System Center, Kyushu University

Bibliographic Information

Other Title
  • イオン液体の経皮吸収促進効果を利用したドラッグデリバリーシステム
  • イオン エキタイ ノ ケイヒ キュウシュウ ソクシン コウカ オ リヨウ シタ ドラッグデリバリー システム

Search this article

Abstract

Transdermal drug delivery system has attracted attention for several advantages over conventional oral or injection route, such as bypassing first–pass effect, safe and painless route, etc., whereas the barrier function of the skin inhibits the drug delivery through the skin. This review focused on transdermal drug delivery system that utilizes ionic liquids (ILs). ILs show the skin penetration enhancing effect by increasing the solubility of drugs, converting lipophilicity of drugs, or by the direct action on the skin structure. We have demonstrated that the incorporation of ILs into emulsion system facilitates the transdermal delivery of poorly soluble drugs and the transcutaneous vaccine delivery.

Journal

  • MEMBRANE

    MEMBRANE 43 (3), 108-, 2018

    THE MEMBRANE SOCIETY OF JAPAN

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top