Treatment of NK/T-cell lymphoma: current situations and prospectives

DOI Web Site PubMed
  • YAMAGUCHI Motoko
    Department of Hematology and Oncology, Mie University Graduate School of Medicine

Bibliographic Information

Other Title
  • NK/T細胞リンパ腫治療の現状と展望
  • NK/Tサイボウ リンパシュ チリョウ ノ ゲンジョウ ト テンボウ

Search this article

Abstract

<p>Prior to the 2000, patients with extranodal NK/T-cell lymphoma, nasal type (ENKL) were typically treated with anthracycline-containing chemotherapy, such as CHOP therapy, and the therapeutic outcomes were unsatisfactory. Since the early 2000s, next-generation therapies without anthracyclines have been developed and tested in clinical trials, markedly changing ENKL treatment. A retrospective, Next-Generation Therapy for NK/T-Cell Lymphoma in East Asia (NKEA) Part A, study in Japan investigated the current state of ENKL management. The results revealed that radiotherapy and dexamethasone, etoposide, ifosfamide, and carboplatin (RT-DeVIC) concurrent chemoradiotherapy was selected as the first-line therapy in 66% patients with localized ENKL, diagnosed between 2010 and 2013 in 31 institutes in Japan. The 5-year overall survival and progression-free survival rates in 150 patients treated with RT-DeVIC in clinical practice were 72% and 61%, respectively, confirming the results of an RT-DeVIC clinical trial. Furthermore, the NKEA study highlighted several limitations of current ENKL management strategies. Now is the time to explore effective therapies for ENKL beyond the current next-generation therapies. International cooperation, utilizing the strengths of each country’s treatment protocols, will contribute to advancement in ENKL treatment.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 59 (5), 588-593, 2018

    The Japanese Society of Hematology

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top