Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice
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- Shimizu Chikako
- Frontier Laboratories for Value Creation, SAPPORO HOLDINGS LTD.
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- Mitani Yutaka
- Frontier Laboratories for Value Creation, SAPPORO HOLDINGS LTD.
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- Tsuchiya Youichi
- Frontier Laboratories for Value Creation, SAPPORO HOLDINGS LTD.
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- Nabeshima Toshitaka
- Fujita Health University Aino University NPO Japanese Drug Organization of Appropriate Use and Research
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<p>Ethanol (EtOH) dosage, frequency, and paired associative learning affect the risk of alcoholism. Recently, Spanagel et al. reported that acamprosate calcium (Acam Ca) prescribed for alcoholism exerts an anti-relapse effect via Ca. Ca is contained in foods, sometimes consumed with alcohol. Therefore, we investigated the association among oral Ca ingestion, EtOH-induced locomotor sensitization, and plasma Ca levels on how to consume Ca for moderate drinking. We used DBA/2 CrSlc mice, and CaCl2 as water-soluble Ca salts. For pre-administration, elemental Ca (50, 75, 100, or 150 mg/kg, per os (p.o.)) or water for control was administered 1 h before EtOH (2 g/kg, 20 v/v (%) EtOH in saline) administration intraperitoneal (i.p.) for locomotor sensitization or for plasma Ca level changes. For post-administration, elemental Ca (100 mg/kg) was administered 1 h after EtOH. Moreover, we employed bepridil and the dopamine D1 antagonist, SCH-23390 to further examine the mechanism of EtOH-induced sensitization. The locomotor sensitization segmentalized for 300 s had two peaks (0–90 s and 180–300 s). Pre-administration of Ca (50, 75, and 100 mg/kg) significantly reduced the 0–90-s peak, selectively blocked by SCH-23390, but “non-dose dependently” as Ca 150 mg/kg did not have this effect. Bepridil blocked the suppressive effect of pre-administration of Ca (100 mg/kg). The effective pre-doses of Ca (50–100 mg/kg) maintained plasma Ca basal levels against EtOH-induced decrease of Ca. On the contrary, post-administration of Ca inversely led to significant promotion of sensitization of both locomotor peaks. Oral Ca intake had diverse effects on EtOH-induced sensitization depending on Ca dosage and timing.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 41 (7), 1049-1061, 2018-07-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001288041383552
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- NII論文ID
- 130007387136
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 029063556
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- PubMed
- 29769465
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
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