Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl
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- Hikiami Ryota
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
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- Yamakado Hodaka
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
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- Tatsumi Shinsui
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
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- Ayaki Takashi
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
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- Hashi Yuichiro
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
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- Yamashita Hirofumi
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
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- Sawamoto Nobukatsu
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
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- Tsuji Teruyuki
- Tsuji Clinic, Japan
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- Urushitani Makoto
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan Department of Neurology, Shiga University of Medical Science, Japan
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- Takahashi Ryosuke
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
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Abstract
<p>We herein report a 15-year-old girl who developed rapid progressive muscle weakness soon after the third injection of a bivalent human papilloma virus (HPV) vaccine. Although immunotherapies were performed for possible vaccine-related disorders, she died of respiratory failure 14 months after the onset of the disease. A genetic analysis identified a heterozygous p.P525L mutation of the fused in sarcoma (FUS) gene, and a histopathological analysis was also consistent with FUS-associated amyotrophic lateral sclerosis (ALS) without any evidence of neuroinflammation. We concluded the diagnosis to be FUS-ALS, although we cannot completely rule out the possibility that the vaccination worked as a trigger. </p>
Journal
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- Internal Medicine
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Internal Medicine 57 (13), 1917-1919, 2018-07-01
The Japanese Society of Internal Medicine