Post-transcriptional regulation of immune responses by RNA binding proteins

DOI Web Site Web Site PubMed 被引用文献4件 参考文献71件
  • MINO Takashi
    Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University
  • TAKEUCHI Osamu
    Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University

この論文をさがす

抄録

<p>Cytokines are critical mediators of inflammation and host immune defense. Cytokine production is regulated at both transcriptional and post-transcriptional levels. Post-transcriptional damping of inflammatory mRNAs is mediated by a set of RNA binding proteins (RBPs) interacting with cis-elements, such as AU-rich elements (ARE) and stem-loop structures. Whereas ARE-binding proteins such as tristetraprolin and a stem-loop recognizing protein, Roquin, downregulate cytokine mRNA abundance by recruiting a CCR4-NOT deadenylase complex, another stem-loop RBP, Regnase-1, acts as an endoribonuclease, directly degrading target cytokine mRNAs. These RBPs control translation-active or -inactive mRNAs in distinct intracellular locations. The presence of various RBPs regulating mRNAs in distinct locations enables elaborate control of cytokines under inflammatory conditions. Dysregulation of cytokine mRNA decay leads to pathologies such as the development of autoimmune diseases or impaired activation of immune responses. Here we review current knowledge about the post-transcriptional regulation of immune responses by RBPs and the importance of their alteration during inflammatory pathology and autoimmunity.</p>

収録刊行物

被引用文献 (4)*注記

もっと見る

参考文献 (71)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ