Emergence of Smoldering ANCA-associated Glomerulonephritis during the Clinical Course of Mixed Connective Tissue Disease and Sjögren's Syndrome
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- Morimoto Chikayuki
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Fujigaki Yoshihide
- Department of Internal Medicine, Teikyo University School of Medicine, Japan Central Laboratory, Teikyo University School of Medicine, Japan
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- Tamura Yoshifuru
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Ota Tatsuru
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Shibata Shigeru
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Asako Kurumi
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Kikuchi Hirotoshi
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Kono Hajime
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Kondo Fukuo
- Department of Pathology, Teikyo University School of Medicine, Japan
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- Yamaguchi Yutaka
- Department of Pathology, Teikyo University School of Medicine, Japan
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- Uchida Shunya
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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抄録
<p>A 67-year-old woman presented with hematuria and proteinuria 16 and 11 months ago, respectively. She had been followed up as mixed connective tissue disease and Sjögren's syndrome for over 19 years. Blood chemistry showed no elevated serum creatinine or C-reactive protein but did reveal myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) of 300 U/dL. A kidney biopsy showed pauci-immune focal necrotizing glomerulonephritis. She was treated with prednisolone and rituximab, resulting in normal urinalysis and decreased MPO-ANCA. The complication of ANCA-associated glomerulonephritis should not be overlooked when abnormal urinalysis findings appear in the course of connective tissue disease, irrespective of the presence of rapidly progressive glomerulonephritis. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 57 (12), 1757-1762, 2018-06-15
一般社団法人 日本内科学会