Successful Application of Edoxaban in the Treatment of Venous Thromboembolism Recurrence in a Patient with Non-small Cell Lung Cancer after Tumor Shrinkage

• Shoji Tetsuaki

  First Department of Medicine, Hokkaido University Hospital, Japan

• Mizugaki Hidenori

  First Department of Medicine, Hokkaido University Hospital, Japan

• Ikezawa Yasuyuki

  First Department of Medicine, Hokkaido University Hospital, Japan

• Furuta Megumi

  First Department of Medicine, Hokkaido University Hospital, Japan

• Takashima Yuta

  First Department of Medicine, Hokkaido University Hospital, Japan

• Kikuchi Hajime

  First Department of Medicine, Hokkaido University Hospital, Japan

• Goudarzi Houman

  First Department of Medicine, Hokkaido University Hospital, Japan

• Asahina Hajime

  First Department of Medicine, Hokkaido University Hospital, Japan

• Kikuchi Junko

  First Department of Medicine, Hokkaido University Hospital, Japan

• Kikuchi Eiki

  First Department of Medicine, Hokkaido University Hospital, Japan

• Sakakibara-Konishi Jun

  First Department of Medicine, Hokkaido University Hospital, Japan

• Shinagawa Naofumi

  First Department of Medicine, Hokkaido University Hospital, Japan

• Tsujino Ichizo

  First Department of Medicine, Hokkaido University Hospital, Japan

• Nishimura Masaharu

  First Department of Medicine, Hokkaido University Hospital, Japan

Abstract

This report describes the case of a 66-year-old man with non-small cell lung cancer and venous thromboembolism (VTE). Unfractionated heparin (UFH) was initially used to control VTE before chemotherapy. However, switching UFH to warfarin or edoxaban, a novel oral anticoagulant (NOAC), failed. Chemotherapy was then administered to control the tumor which was thought to have been the main cause of VTE, which had been treated by UFH. After tumor shrinkage was achieved by chemotherapy, we were able to successfully switch from UFH to edoxaban. Controlling the tumor size and activity enabled the use of edoxaban as maintenance therapy for VTE.

Journal

• Internal Medicine

  Internal Medicine 57 (12), 1769-1772, 2018-06-15

  The Japanese Society of Internal Medicine

Keywords

• lung cancer
• venous thromboembolism
• novel oral anticoagulants
• direct oral anticoagulants
• tumor shrinkage
• tumor volume

Details

• CRID: 1390845712967961856
• NII Article ID: 130007397149
• DOI: 10.2169/internalmedicine.9741-17
• ISSN: 13497235
• ISSN: 09182918
• PubMed: 29434159
• Web Site: https://www.jstage.jst.go.jp/article/internalmedicine/57/12/57_9741-17/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019252671
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed