Inhibitory Activity of Hydroxytyrosol against Streptolysin O-Induced Hemolysis
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- SOGAWA KAZUYUKI
- School of Life and Environmental Science, Azabu University
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- KOBAYASHI MIKA
- School of Life and Environmental Science, Azabu University
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- SUZUKI JUN
- School of Life and Environmental Science, Azabu University
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- SANDA AKIHIRO
- School of Life and Environmental Science, Azabu University
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- KODERA YOSHIO
- School of Science, Kitasato University
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- FUKUYAMA MASAFUMI
- School of Life and Environmental Science, Azabu University
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抄録
<p> Group A streptococcus is a bacterium that resides in the throat and skin and causes respiratory infection and occasionally glomerulonephritis and rheumatic fever. Streptolysin O (SLO) produced by Streptococcus pyogenes (S. pyogenes) binds to the cell membrane, particularly to that of white and red blood cells, and is toxic to the cells and tissue. In this study, we evaluated the inhibitory activity of water-soluble polyphenols in olives (Olea europaea) against SLO-induced hemolysis. Hydroxytyrosol inhibited SLO-induced hemolytic activity, and the amount required for 50% inhibition of hemolysis was 1.30 µg. These findings suggest that the water-soluble polyphenols contained in olives have inhibitory activity against SLO-induced hemolysis.</p>
収録刊行物
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- Ｂｉｏｃｏｎｔｒｏｌ Ｓｃｉｅｎｃｅ
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Ｂｉｏｃｏｎｔｒｏｌ Ｓｃｉｅｎｃｅ 23 (2), 77-80, 2018
日本防菌防黴学会
