Effects of l-carnitine and branched-chain amino acids on energy metabolism, body composition and delayed-onset muscle soreness after exercise in normal healthy subjects

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  • Sakurai Yoichi
    Department of Ecology, Wayo Women’s University Graduate School Department of Surgery, Chiba-ken Saiseikai Narashino Hospital
  • Hasegawa Yumi
    Department of Ecology, Wayo Women’s University Graduate School Department of Clinical Nutrition, Matsudo Municipal Hospital
  • Namba Hideyuki
    College of Science and Technology, Nihon University
  • Odo Satoshi
    Lonza Japan

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  • 健常者におけるL-カルニチン＋分岐鎖アミノ酸投与後運動負荷のエネルギー代謝･体組成に対する効果に関する基礎的検討
  • ケンジョウシャ ニ オケル L-カルニチン+ブンキ サ アミノサン トウヨ ゴ ウンドウ フカ ノ エネルギー タイシャ ・ カラダ ソセイ ニ タイスル コウカ ニ カンスル キソテキ ケントウ

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Abstract

<p>Backgrounds: Specific nutrients combined with exercise are expected to prevent loss of lean body mass, and consequently prevent sarcopenia. The effects of 2 weeks of L-carnitine (LCAR) supplementation associated with branched-chain amino acid (BCAA) on energy metabolism, body composition before and after exercise and post-exercise muscle soreness were examined in normal healthy subjects.</p><p>Methods: A total of 12 young untrained healthy women were randomly assigned to 2 groups who received either 2 weeks of LCAR (1000 mg/day) associated with branched-chain amino acid and 200 kcal energy (LCAR+BCAA Group, n=6) or 200 kcal energy alone (Control Group, n=6) before the 60 min exercise. Energy substrate metabolism, body composition was examined before and after exercise and delayed-onset muscle soreness (DOMS) was evaluated using VAS scale for 3 days after exercise.</p><p>Results: Serum concentrations of free and acyl LCAR in LCAR+BCAA Group were not significantly different from those in Control group. There was no difference of body composition before and after exercise between two groups. While serum free fatty acid level in LCAR+BCAA Group 120 min after the oral ingestion of BCAA was significantly lower than in Control group, there was no difference of serum free fatty acid level just after and 60 min after exercise. DOMS in LCAR+BCAA group for 3 days after exercise was lower than in Control group.</p><p>Conclusion: Continuous LCAR with BCAA in young untrained healthy subjects caused blunted response of stimulated lipolysis in LCAR+BCAA Group after exercise.</p>

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