Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an <i>in vivo</i> evaluation system
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- Ishii Masaki
- Genome Pharmaceuticals Institute Co., Ltd.
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- Matsumoto Yasuhiko
- Teikyo University Institute of Medical Mycology
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- Sekimizu Kazuhisa
- Genome Pharmaceuticals Institute Co., Ltd. Teikyo University Institute of Medical Mycology
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抄録
<p>Cyclodextrins (CyDs) are cyclic oligosaccharides consisting of six to eight glucose residues. Administration of α-CyD (six glucose residues) inhibits sucrose-induced hyperglycemia in humans. Here we show that oral administration of α-CyD and dimethyl α-CyD suppresses sucrose-induced hyperglycemia in an in vivo evaluation system using silkworms. On the other hand, β-CyD (seven glucose residues), γ-CyD (eight glucose residues), and their derivatives did not show the suppressive effect. These findings suggest that dimethyl α-CyD is a new inhibitor against sucrose-induced hyperglycemia and the silkworm system is useful for evaluation of suppressive activities of α-CyD derivatives against postprandial hyperglycemia.</p>
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 12 (3), 122-125, 2018-06-30
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会