Proanthocyanidin-rich grape seed extract prevent estrogen deficiency-induced metabolic disorders

Access this Article

Search this Article

Author(s)

    • Jin Guangwen
    • Department of Orthopedic Surgery, Tokyo Medical and Dental University|Department of Orthopedic Surgery, Yanbian University Hospital
    • Okawa Atsushi
    • Department of Orthopedic Surgery, Tokyo Medical and Dental University
    • Asou Yoshinori
    • Department of Orthopedic Surgery, Tokyo Medical and Dental University
    • Piao Jinying
    • Department of Orthopedic Surgery, Tokyo Medical and Dental University
    • Koga Daisuke
    • Department of Orthopedic Surgery, Tokyo Medical and Dental University
    • Ochi Hiroki
    • Department of Physiology and Cell Biology, Tokyo Medical and Dental University
    • Ishiyama Kirika
    • Laboratory for Redox Regulation, Tohoku University Graduate School of Dentistry
    • Kanno Taro
    • Laboratory for Redox Regulation, Tohoku University Graduate School of Dentistry
    • Niwano Yoshimi
    • Laboratory for Redox Regulation, Tohoku University Graduate School of Dentistry

Abstract

The postmenopausal state is associated with an increased risk of metabolic syndrome. Grape seed extract (GSE), a rich source of proanthocyanidins, has beneficial effects on low-grade inflammatory diseases in a high-fat diet-induced obesity model and therefore is a candidate to improve postmenopausal metabolic abnormalities. In the present study, the effects of dietary GSE on body weight and glucose tolerance were examined in ovariectomized (OVX) mice. Female C57BL6/J mice underwent ovariectomy or a sham operation, and OVX mice were orally administered GSE (100 mg/ kg B.W.) or the vehicle solution (OVX+V). Mice in the OVX+V group weighed significantly more than mice in the Sham group. Body weight was significantly lower in the OVX+GSE group than in the OVX+V group. The weights of subcutaneous white adipose tissue (WAT) and visceral WAT were significantly lower in the OVX+GSE group than in the OVX+V group. In glucose tolerance tests, OVX+GSE mice showed significantly lower blood glucose levels at 30 min and 60 min than those in OVX+V mice. In conclusion, we demonstrated that GSE prevents metabolic disorders, such as obesity and glucose intolerance, in OVX mice. These results support the potential therapeutic applications of GSE in postmenopausal women.

Journal

  • Journal of Medical and Dental Sciences

    Journal of Medical and Dental Sciences 65(2), 45-50, 2018

    Tokyo Medical and Dental University

Codes

  • NII Article ID (NAID)
    130007410283
  • Text Lang
    ENG
  • Article Type
    departmental bulletin paper
  • ISSN
    1342-8810
  • Data Source
    IR  J-STAGE 
Page Top