Proanthocyanidin-rich grape seed extract prevent estrogen deficiency-induced metabolic disorders
-
- Jin Guangwen
- Department of Orthopedic Surgery, Tokyo Medical and Dental University Department of Orthopedic Surgery, Yanbian University Hospital
-
- Aobulikasimu Alkebaier
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
-
- Piao Jinying
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
-
- Aibibula Zulipiya
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
-
- Koga Daisuke
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
-
- Ochi Hiroki
- Department of Physiology and Cell Biology, Tokyo Medical and Dental University
-
- Ishiyama Kirika
- Laboratory for Redox Regulation, Tohoku University Graduate School of Dentistry
-
- Kanno Taro
- Laboratory for Redox Regulation, Tohoku University Graduate School of Dentistry
-
- Niwano Yoshimi
- Laboratory for Redox Regulation, Tohoku University Graduate School of Dentistry
-
- Okawa Atsushi
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
-
- Asou Yoshinori
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
この論文をさがす
抄録
The postmenopausal state is associated with an increased risk of metabolic syndrome. Grape seed extract (GSE), a rich source of proanthocyanidins, has beneficial effects on low-grade inflammatory diseases in a high-fat diet-induced obesity model and therefore is a candidate to improve postmenopausal metabolic abnormalities. In the present study, the effects of dietary GSE on body weight and glucose tolerance were examined in ovariectomized (OVX) mice. Female C57BL6/J mice underwent ovariectomy or a sham operation, and OVX mice were orally administered GSE (100 mg/ kg B.W.) or the vehicle solution (OVX+V). Mice in the OVX+V group weighed significantly more than mice in the Sham group. Body weight was significantly lower in the OVX+GSE group than in the OVX+V group. The weights of subcutaneous white adipose tissue (WAT) and visceral WAT were significantly lower in the OVX+GSE group than in the OVX+V group. In glucose tolerance tests, OVX+GSE mice showed significantly lower blood glucose levels at 30 min and 60 min than those in OVX+V mice. In conclusion, we demonstrated that GSE prevents metabolic disorders, such as obesity and glucose intolerance, in OVX mice. These results support the potential therapeutic applications of GSE in postmenopausal women.
収録刊行物
-
- Journal of Medical and Dental Sciences
-
Journal of Medical and Dental Sciences 65 (2), 45-50, 2018
国立大学法人 東京医科歯科大学
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001288038916480
-
- NII論文ID
- 130007410283
-
- ISSN
- 21859132
- 13428810
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可