Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan
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- Kubota Takuo
- Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Nakayama Hirofumi
- Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Kitaoka Taichi
- Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Nakamura Yosikazu
- Department of Public Health, Jichi Medical University, Tochigi 329-0498, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Fukumoto Seiji
- Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima 770-8503, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Fujiwara Ikuma
- Department of Pediatric Endocrinology and Environmental Medicine, Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Hasegawa Yukihiro
- Division of Endocrinology and Metabolism, Tokyo Metropolitan Children’s Medical Center, Tokyo 183-8561, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Ihara Kenji
- Department of Pediatrics, Oita University Faculty of Medicine, Oita 879-5593, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Kitanaka Sachiko
- Department of Pediatrics, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Koyama Satomi
- Department of Pediatrics, Dokkyo Medical University, Tochigi 321-0293, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Kusuda Satoshi
- Department of Pediatrics, Kyorin University, Tokyo 181-0004, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Mizuno Haruo
- Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Aichi 467-8602, Japan Department of Pediatrics, International University of Health and Welfare, School of Medicine, Chiba 286-8686, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Nagasaki Keisuke
- Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8520, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Oba Koji
- Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Sakamoto Yuko
- Department of Orthopedics, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Takubo Noriyuki
- Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Shimizu Toshiaki
- Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Tanahashi Yusuke
- Department of Pediatrics, Asahikawa Medical University, Hokkaido 078-8510, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Hasegawa Kosei
- Department of Pediatrics, Okayama University Hospital, Okayama 700-8558, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Tsukahara Hirokazu
- Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Yorifuji Tohru
- Division of Pediatric Endocrinology and Metabolism, Children’s Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Michigami Toshimi
- Department of Bone and Mineral Research, Research Institute, Osaka Women’s and Children’s Hospital, Osaka 594-1101, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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- Ozono Keiichi
- Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D
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抄録
<p>There is concern that vitamin D deficiency is prevalent among children in Japan as well as worldwide. We conducted a nationwide epidemiologic survey of symptomatic vitamin D deficiency to observe its incidence rate among Japanese children. A questionnaire inquiring the number of new patients with vitamin D deficiency rickets and/or hypocalcemia for 3 years was sent to 855 randomly selected hospitals with a pediatrics department in Japan. In this survey, we found that 250 children were diagnosed with symptomatic vitamin D deficiency. The estimated number of patients with symptomatic vitamin D deficiency per year was 183 (95% confidence interval (CI): 145–222). The overall annual incidence rate among children under 15 years of age was 1.1 per 100,000 population (95% CI: 0.9–1.4). The second survey has provided detailed information on 89 patients with symptomatic vitamin D deficiency under 5 years of age in hospitals in the current research group. The nationwide and second surveys estimated the overall annual incidence rate of symptomatic vitamin D deficiency in children under 5 years of age to be 3.5 (2.7–4.2) per 100,000 population. The second survey revealed 83% had bowed legs, 88% had exclusive breastfeeding, 49% had a restricted and/or unbalanced diet and 31% had insufficient sun exposure among the 89 patients. This is the first nationwide survey on definitive clinical vitamin D deficiency in children in Japan. Elucidating the frequency and characteristics of symptomatic vitamin D deficiency among children is useful to develop preventative public health strategies.</p>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 65 (6), 593-599, 2018
一般社団法人 日本内分泌学会