Time Course of Decrease in Skeletal Muscle Mitochondrial Biogenesis after Discontinuation of High-Fat Diet

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  • LI Xi
    Graduate School of Sport Sciences, Waseda University
  • HIGASHIDA Kazuhiko
    Faculty of Sport Sciences, Waseda University Institute of Advanced Active Aging Research, Waseda University Department of Food Science and Nutrition, The University of Shiga Prefecture
  • KAWAMURA Takuji
    Graduate School of Sport Sciences, Waseda University
  • HIGUCHI Mitsuru
    Faculty of Sport Sciences, Waseda University Institute of Advanced Active Aging Research, Waseda University

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Abstract

It is known that a high-fat diet induces an increase in mitochondrial biogenesis in skeletal muscle. To examine the time course of decrease in mitochondrial biogenesis in skeletal muscle after discontinuing a high-fat diet feeding, C57BL/6 mice were fed a high-fat diet for 4 wk and then switched to the control diet for another 3 or 7 d. During the high-fat diet withdrawal period, the protein content of the mitochondrial respiratory chain decreased faster than the fatty acid oxidation enzymes. The mitochondrial DNA copy number remained high for at least 1 wk after withdrawing the high-fat diet. These results suggested that after switching to the control diet following a period of high-fat diet, the increased mitochondrial biogenesis levels are maintained for a few days, and the rate of decline is divergent between the different mitochondrial components.

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